Release date: 2012-10-10 In a study of how transplanted islet cells can differentiate and mature into insulin-producing pancreatic cells, a team from Nagoya University in Japan found that a mouse influenza virus called Sendai virus (SeV) was used as a carrier. A group of specific transcription factors can be transduced into mouse pancreatic stem cells (mPSCs). The results of the study were recently published in the Cell Medicine journal and can be downloaded free of charge online. Paper co-author Hiroshi Yukawa said, "Diabetes is one of the most serious and epidemic metabolic diseases. Islet cell transplantation has proven to be effective, but this strategy requires enough donor organs." Given the shortage of donor organs, researchers Using mouse virus SeV to introduce different combinations of transcription factors into pancreatic stem cells to study transcription factors that can affect pancreatic stem cell proliferation and differentiation into insulin-producing cells, thereby increasing the number of functional islet cells for transplantation. The researchers say that SeV viral vectors are superior to conventional viral vectors because "they (when replicating) do not undergo a DNA phase" and are capable of non-toxic introduction of foreign genes into multiple cell types. The combination of transcription factors that have the greatest impact on the differentiation of pancreatic stem cells into insulin-producing cells is Pdx-1 (Pancreatic and duodenal homeobox 1, pancreatic duodenal homeobox gene-1), NeuroD (neurogenic dMafA (musculoaponeurotic fibrosarcoma oncogene A). , Tendon fibrosarcoma oncogene A). The researchers concluded that "our data suggest that the introduction of transcription factors using the SeV viral vector can promote the differentiation of mouse pancreatic stem cells into insulin-producing cells, making it possible to utilize transduced pancreatic stem cells. Regeneration of islet beta cells." Source: Bio Valley
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