What is THCPO and what are its effects?

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THCPO, or Tetrahydrocannabiforol-O Acetate, is essentially a chemically modified version of THCP, created through acetylation of the hydroxyl group. In simpler terms, this means it’s a synthetic derivative of THCP, which itself is structurally similar to THC—the primary psychoactive compound found in cannabis. While THCP can be directly extracted from the plant, THCPO exists solely in the lab. It was first synthesized back in 2021. One key advantage of THCPO over THCP is its enhanced thermal and oxidative stability, leading to a longer shelf life. Another distinguishing feature is its longer side chain, which consists of seven carbons instead of the usual five in regular THC. This structural difference results in significantly more potent effects that can last much longer—up to eight hours compared to the typical four-hour duration with THC. ![THCPO Structure](http://bsg-i.nbxc.com/blog/fec3f730d7db96b50378d5fd5e7382ea.png) ![Comparison Chart](http://bsg-i.nbxc.com/blog/c0dabf541b37d74f07d998333783bc3f.png) ### What Are the Effects of THCPO? As noted earlier, THCPO is far more potent than THCP due to its additional acetate group. Scientific research suggests that THCP exhibits up to 30 times greater activity at the human CB1 receptor compared to THC. With its high binding affinity for CB1 receptors in the brain, THCPO delivers powerful psychoactive experiences. Even seasoned cannabis users might find themselves caught off guard by its intensity, making it unsuitable for newcomers. Beyond just its chemical makeup, THCPO induces classic psychoactive sensations like euphoria and relaxation. Users often report altered perceptions, where they feel changes in how they experience time and space. These effects typically persist for several hours. On the therapeutic front, THCPO offers promising benefits such as alleviating chronic pain. Much like CBD, it may also help reduce anxiety levels among users. However, it’s worth mentioning that there are currently no specific studies focusing exclusively on THCPO. Our understanding largely stems from extrapolations based on related compounds subjected to similar chemical modifications. ### Possible Side Effects Like other psychoactive cannabinoids, THCPO could potentially cause side effects such as bloodshot eyes, drowsiness, dry mouth, and occasional paranoia. These symptoms usually subside within a few hours. Nevertheless, given the scarcity of long-term research, the potential impacts of prolonged use remain unclear. ### How Does THCPO Compare to HHC? HHC represents a hydrogenated form of THC, featuring an extra pair of hydrogen atoms compared to its natural counterpart. This tweak enhances its stability while maintaining structural similarity to THC. Unlike THCPO, HHC occurs naturally within cannabis plants. When comparing their effects, THCPO generally produces stronger and more pronounced outcomes than HHC. Both substances deliver therapeutic advantages, yet THCPO tends to offer superior relief from pain and anxiety. Conversely, its adverse reactions—such as vivid hallucinations or severe redness—are also more pronounced. ### Available THCPO Products Today, THCPO-based vapes and cartridges dominate the market, appealing to consumers thanks to their diverse flavor options. Many of these products incorporate additional cannabinoids alongside THCPO, including HHC-P and THCP. You can also find CBD flower varieties infused with THCPO distillate. ![Vape Pens](http://bsg-i.nbxc.com/blog/448e62cc1aa46734f394443517e9806a.png) ![Infused Flowers](http://bsg-i.nbxc.com/blog/b8be17f19c214bc97b3face181459175.png) ### Final Thoughts Given the potency of THCPO, it’s crucial to approach it cautiously, especially when trying it for the first time. Always start with minimal doses to gauge your personal tolerance level, as individual responses vary greatly. Remember, what works well for one person might not suit another due to differences in physiology and sensitivity.

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