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Researchers at the University of Michigan recently succeeded in cultivating artificial bone marrow, which has the function of replicating blood stem cells and producing B cells. The results of this study are expected to help people simplify drug testing, better study immune system defects, and continue to supply blood for blood transfusion.
Research project leader Nicholas Kutuf said that this is the first successful acquisition of artificial bone marrow, which has two basic functions of bone marrow, namely, copying blood stem cells and producing B cells. The latter is an important immune cell that produces antibodies against disease. B cells are white blood cells that are resistant to bacterial infections and other foreign or abnormal cells, including certain cancer cells. Blood stem cells produce blood cells and several other cells.
Kutuf said that the bone marrow is a very complex organization. The key to their successful acquisition of artificial bone marrow is a three-dimensional grid scaffold on which the bone marrow can grow. The grid has a large number of standard pores that stimulate cell-cell interactions. The grid bracket is made of a transparent polymer material that allows nutrients to pass easily. To create a grid bracket, the researchers first used a number of tiny spheres to form with the polymer material, but dissolved the spheres to obtain a grid bracket with a perfect small hole geometry. After "sowing" bone marrow stromal cells and osteoblasts onto the grid scaffold, the researchers harvested artificial bone marrow. To test whether artificial bone marrow can function like real bone marrow, the researchers transplanted it into experimental mice with immunodeficiency, and the mice produced human immune cells.
Kutuf said the new artificial bone marrow will allow researchers to understand how certain variants of new drugs affect bone marrow, which will help drug development and allow people to know the serious side effects of drugs before they enter clinical trials. . Shanghai Medical Device Industry Association