U.S. successfully uses gene therapy to cure leukemia

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Business News Agency August 16 US researchers recently reported that they successfully used gene therapy to cure two patients with advanced chronic lymphocytic leukemia for the first time, providing a new approach for the treatment of this disease.

In a clinical trial in which 3 patients participated, researchers at the University of Pennsylvania implanted a gene from a patient's T cells via a lentiviral vector, which was then cultivated in the laboratory and subsequently genetically modified. The T cells are re-implanted into the patient. These special T cells can proliferate in patients and attack tumor cells.

About two weeks later, the cancer cells began to die. "In 3 weeks, the tumor disappeared in a dramatic way that we had never expected." Michael Carlos, who participated in the study, said, "The effect is much better than we expected."

These T cells can persist in patients for 6 months and continue to attack tumor cells. At present, the condition in which no tumor cells have been found in two patients has been maintained for one year, and the third patient's condition has also improved. The researchers plan to recruit 4 new patients for treatment.

The researchers said that this achievement provides a "road map" for the treatment of other cancers. However, some scientists believe that the number of participants in this clinical trial is too small, and further study of gene therapy for leukemia is needed.

This research result was recently published in the United States "New England Journal of Medicine" and "Scientific translation medicine" magazine.

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