Mobile medical researchers are expected to monitor human body data through techniques such as tattooing and skin grafting

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Release date: 2017-11-13

Researchers from Harvard and MIT are working on a sensor. It can be tattooed on the skin, and when certain biomarkers (such as glucose, sodium) change drastically, the color of the tattoo changes accordingly.

In the latest project development, researchers are working hard to overcome the limitations of the size of wearable devices and develop a sensor that can be worn with only a tattoo.

The Deep Leather Project is a joint project between MIT and Harvard Medical School. Researchers at both partners used color-changing biosensors to replace traditional tattoo inks. After the skin is connected to the sensor, the sensor can sense changes in the interstitial fluid of the human body. For example, when biomarkers such as glucose and sodium change, the color of the sensor changes.

Ali Yetisen, a postdoctoral researcher at Harvard University and the Massachusetts Institute of Technology, told the Harvard communique: "We have been imagining the next generation of wearable products, so now we have the idea of ​​implanting biosensors into the skin."

Yetisen and his colleagues emphasize that the project is currently only used for academic research, but in the future this tattoo technology can be applied to detect hyperglycemia, hypoglycemia, dehydration, or a change in a human biomarker caused by a chronic disease. The patient's post-discharge status can be monitored remotely.

For those who are resistant to tattoos, researchers can use a special kind of ink that is usually invisible and can only be seen when illuminated by a specific color of light.

Although the so-called smart tattoo avoids the drawbacks of traditional wearable devices such as battery life and wireless connection, it has high requirements for fast color reflection and wear resistance.

The concept of implanting biosensors into tattoos is quite new in the health care arena, but at Tel Aviv University, the University of Tokyo and the University of California-San Diego, researchers are studying the use of wristbands, watches, sleeves, etc. The mobile medical sensor is in contact with the skin. In addition, some businesses and health agencies have been experimenting with projects like tattoos that can be applied directly to human skin.

In 2015, researchers at the University of Texas at Austin developed a solar bioelectronic tattoo made of metal and silicon that was applied to human skin by electrostatic forces rather than adhesives. Various vital signs and muscle movements.

Assistant professor Nansha Lu told UT News: "The most attractive aspect of the epidermis electronic device is that it is disposable, no charging, no wireless connection, if we can reduce its cost to a very low level, say One dollar, this will open the door to many mobile medical and other applications."

In February last year, researchers at North Carolina State University received a $1.5 million federal grant to develop wearable sensors that continuously monitor the oxygen content of surrounding tissues. A smart bandage developed by Profusa to help clinicians treat patients with peripheral arterial disease (PAD).

Dr. Natalie Wisniewski, chief technology officer and program leader of Profusa, said in a press release: "The project we have developed in cooperation with our company is a bandaged optical reader that is flexible and disposable, and is suitable for monitoring PAD. This collaborative development is a revolution in patients undergoing revascularization and restenosis during tissue oxygenation, not just for PAD patients, but also for a wide range of mobile health surveillance areas."

At the same time, a survey was conducted at Brigham and Women's Hospital in Boston to confirm whether biosensors developed by Vital Connect can help clinicians remotely monitor heart failure, pneumonia, COPD, cellulitis or complex urinary tracts. Infected patients, these monitoring behaviors are not done in the hospital, but in the patient's home.

Valeska Schroeder, senior vice president of product management at Vital Connect, said at a product exhibition held in Las Vegas by the company: "Five years ago, no one was talking about it because the implementation technology really didn't exist, but It has now become a reality."

At the same time, another company called MC10 has developed three patch products: UV patches developed in collaboration with skin care company L'Oreal, which can be used to monitor the effects of sunlight on the skin; BioStampRC, which measures heart rate, etc. Biometric signal; WiSP, a heart monitoring patch.

Source: Zhi Medical (micro signal mhealth-cn)

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