Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8

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Model NO.: 99%
CAS: 148553-50-8
Trademark: TJ
Transport Package: Camouflage Package
Specification: White powder
Origin: China
HS Code: 3001200090
Model NO.: 99%
CAS: 148553-50-8
Trademark: TJ
Transport Package: Camouflage Package
Specification: White powder
Origin: China
HS Code: 3001200090
Quick Detail:
Synonym: Pregablin;3-(Aminomethyl)-5-methyl-hexanoic acid
CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
Assay: 99.5%
Appearance: White Crystal Powder
Payment: T/T, Western Union and Money Gram
Delivery: Within 24hours After Your Payment
Express: EMS, DHL, FedEx, etc(door-to-door)
Usage: New antiepileptic drugs. Used in the treatment of peripheral neuropathy, or partial seizures adjuvant treatment.

Description:
Pregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23. 
 
Pregabalin is a white to off-white, crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is 1.35.

LYRICA (pregabalin) Capsules are administered orally and are supplied as imprinted hard-shell capsules containing 25, 50, 75, 100, 150, 200, 225, and 300 mg of pregabalin, along with lactose monohydrate, cornstarch, and talc as inactive ingredients. The capsule shells contain gelatin and titanium dioxide. In addition, the orange capsule shells contain red iron oxide and the white capsule shells contain sodium lauryl sulfate and colloidal silicon dioxide. Colloidal silicon dioxide is a manufacturing aid that may or may not be present in the capsule shells. The imprinting ink contains shellac, black iron oxide, propylene glycol, and potassium hydroxide.

COA:

ITEMS STANDARDS RESULTS
Appearance A white to off white powder White powder
Identification A. Meets the requirement Complies
B. IR: similar to Reference Substance Complies
Loss on drying ≤0.5% 0.21%
Specific Rotation +10.0°~+13.0° +10.8°
Related Substances Any single impurity ≤0.1%
Total impurity ≤0.8%		 0.05%
0.10%
Purity By HPLC R-isomer ≤0.15% 0.10
Residue on ignition ≤0.1% 0.05%
Residual solvents Isopropyl alcohol ≤5000ppm
Ethyl Acetate ≤5000ppm		 150ppm
250ppm
Heavy metals ≤10ppm Complies
Chlorides ≤0.05% Complies
Assay 98%~102.0% 99.8%
Conclusion Analyse according to Factory Standard , Conform

Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8

Function:
1. Pharmacological efficacy: Pregabalin is a novel γ-aminobutyric acid (GABA) receptor agonist, can block the voltage-dependent calcium channels to reduce neurotransmitter release.
2. The main clinical for the treatment of peripheral neuropathic pain as well as part of adjuvant treatment of focal seizures.

3. Treatment of epilepsy in developing the most promising drug in a drug treatment better and more convenient administration. Can also be used to treat pain and anxiety.

Pregabalin is a kind of new antiepileptic drugs, with gamma aminobutyric acid structure of its molecular structure, so it has anticonvulsant effect, by the Pfizer Inc developed successfully for the treatment of peripheral neuropathy, or adjunctive treatment of partial seizures. These are the two most common neuropathic pain in the treatment of diabetic peripheral nerve pain (DPN) and postherpetic neuralgia (PHN).

Neuropathic pain is a chronic pain syndrome is one of the most difficult to treat, with dull pain, burning, tingling as the main features, causes of neuropathic pain, diabetes, infections (such as herpes zoster), cancer and AIDS can cause nerve pain, in Europe, about 3% of the population suffering from the pain of god. New antiepileptic drugs

Our adwantage:
1, High quality with competitive price:
    1) Standard: Enterprise Standard
    2) All Purity≥98%
    3) We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
    1) Parcel can be sent out within 24 hours after payment. Tracking number available
    2) Secure and discreet shipment. Various transportation methods for your choice.
    3) Customs pass rate ≥99%
    4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and      we have stock in there for transferring.

3, We have clients throughout the world.
    1) Professional service and rich experience make customers feel at ease, adequate stock and fast                delivery meet their desire.
    2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our            responsibility.
    3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the                customers.
 
Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8

  Quick Detail:
Synonym: Pregablin;3-(Aminomethyl)-5-methyl-hexanoic acid
CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
Assay: 99.5%
Appearance: White Crystal Powder
Payment: T/T, Western Union and Money Gram
Delivery: Within 24hours After Your Payment
Express: EMS, DHL, FedEx, etc(door-to-door)
Usage: New antiepileptic drugs. Used in the treatment of peripheral neuropathy, or partial seizures adjuvant treatment.

Description:
Pregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23. 
 
Pregabalin is a white to off-white, crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is 1.35.

LYRICA (pregabalin) Capsules are administered orally and are supplied as imprinted hard-shell capsules containing 25, 50, 75, 100, 150, 200, 225, and 300 mg of pregabalin, along with lactose monohydrate, cornstarch, and talc as inactive ingredients. The capsule shells contain gelatin and titanium dioxide. In addition, the orange capsule shells contain red iron oxide and the white capsule shells contain sodium lauryl sulfate and colloidal silicon dioxide. Colloidal silicon dioxide is a manufacturing aid that may or may not be present in the capsule shells. The imprinting ink contains shellac, black iron oxide, propylene glycol, and potassium hydroxide.

COA:

ITEMS STANDARDS RESULTS
Appearance A white to off white powder White powder
Identification A. Meets the requirement Complies
B. IR: similar to Reference Substance Complies
Loss on drying ≤0.5% 0.21%
Specific Rotation +10.0°~+13.0° +10.8°
Related Substances Any single impurity ≤0.1%
Total impurity ≤0.8%		 0.05%
0.10%
Purity By HPLC R-isomer ≤0.15% 0.10
Residue on ignition ≤0.1% 0.05%
Residual solvents Isopropyl alcohol ≤5000ppm
Ethyl Acetate ≤5000ppm		 150ppm
250ppm
Heavy metals ≤10ppm Complies
Chlorides ≤0.05% Complies
Assay 98%~102.0% 99.8%
Conclusion Analyse according to Factory Standard , Conform

Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8

Function:
1. Pharmacological efficacy: Pregabalin is a novel γ-aminobutyric acid (GABA) receptor agonist, can block the voltage-dependent calcium channels to reduce neurotransmitter release.
2. The main clinical for the treatment of peripheral neuropathic pain as well as part of adjuvant treatment of focal seizures.

3. Treatment of epilepsy in developing the most promising drug in a drug treatment better and more convenient administration. Can also be used to treat pain and anxiety.

Pregabalin is a kind of new antiepileptic drugs, with gamma aminobutyric acid structure of its molecular structure, so it has anticonvulsant effect, by the Pfizer Inc developed successfully for the treatment of peripheral neuropathy, or adjunctive treatment of partial seizures. These are the two most common neuropathic pain in the treatment of diabetic peripheral nerve pain (DPN) and postherpetic neuralgia (PHN).

Neuropathic pain is a chronic pain syndrome is one of the most difficult to treat, with dull pain, burning, tingling as the main features, causes of neuropathic pain, diabetes, infections (such as herpes zoster), cancer and AIDS can cause nerve pain, in Europe, about 3% of the population suffering from the pain of god. New antiepileptic drugs

Our adwantage:
1, High quality with competitive price:
    1) Standard: Enterprise Standard
    2) All Purity≥98%
    3) We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
    1) Parcel can be sent out within 24 hours after payment. Tracking number available
    2) Secure and discreet shipment. Various transportation methods for your choice.
    3) Customs pass rate ≥99%
    4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and      we have stock in there for transferring.

3, We have clients throughout the world.
    1) Professional service and rich experience make customers feel at ease, adequate stock and fast                delivery meet their desire.
    2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our            responsibility.
    3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the                customers.
 
Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8

 

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