Pharmaceutical Antiobesity Agent Raw Powder Orlistat for Weight Loss

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  • Model NO.: 96829-58-2
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >99%
  • CAS: 96829-58-2
  • MW: 495.73
  • Melting Point: <50 °c
  • Delivery Time: Within 24 Hours After We Get Your Payment
  • Transport Package: Discreet Package
  • Origin: China
  • Powder: Yes
  • Certification: HSE, ISO 9001
  • State: Solid
  • Synonym: Orlipastat
  • Mf: C29h53no5
  • Appearance: White or Kind of White Crystalline Powder
  • Usage: Used for Curing Obesity.
  • Trademark: Saichuang
  • Specification: Enterprise standard
Pharmaceutical Antiobesity Agent Raw Powder Orlistat For Weight Loss


Basic Information
Produt Name
Orlistat
 
Synonym
Orlipastat
 
CAS
96829-58-2
 
MF
C29H53NO5
 
MW
495.73
 
Purity
98.0%
 
Melting point
<50 °C
 
Appearance
White or kind of white crystalline powder, soluble in water.
 
Usage
Used for curing obesity
 
Specification
1 kg/bag
 


What is Orlistat?

Orlistat is a white to off-white crystalline powder. Orlistat is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. Orlistat has no pKa within the physiological pH range.

Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. In the intestine, an enzyme called lipase (produced primarily by the pancreas) breaks apart fat in food so that it can be absorbed into the body. Orlistat blocks the action of lipase and thereby prevents the breakup and absorption of fat. Orlistat blocks absorption of about 25% of the fat in a meal. The unabsorbed fat is excreted in the stool. The FDA approved Orlistat by prescription in 1999. 

Description

Orlistat (also known as tetrahydrolipstatin) is a drug designed to treat obesity. It is marketed as a prescription drug under the trade by Roche in most countries, and is sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States.Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.

Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini.However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug.

Application

The effectiveness of orlistat in promoting weight loss is definite, though modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2-3 kilograms (4.4-6.6 lb) more than those not taking the drug over the course of a year.Orlistat also modestly reduces blood pressure, and appears to prevent the onset of type 2 diabetes, whether due to weight loss itself or to other effects; in a large randomized controlled trial, orlistat was found to reduce the incidence of diabetes by nearly 40% in obese people.

Orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). These decrease with time, however, and are the most frequently reported adverse effects of the drug.In the United States and the European Union, orlistat is available for sale without a prescription. Over-the-counter approval was controversial in the United States, with consumer advocacy group Public Citizen repeatedly opposing it on safety and efficacy grounds.Generic formulations of orlistat are available in some countries. In Australia it is listed as an S3 medication, which means it's available over the counter in pharmacies.


COA
 Items  Standard  Results
 Description  White to kind of white powder  kind of white powder
 Melting point  193.0-200  196.0-198.9
 Water  5-6.5%  5.6%
 Solubility  Soluble in methanol  Complies
 PH  4.0-6.0  5
 Heavy Metals  <10ppm  Complies
 Assay  >96%  99.5%
 Residue on ignition  <0.1%  0.03%
 Single impurity  <0.2%  0.19%
 Conclusion  Up to the Standard USP 32.


Usage

1. An antiobesity agent. A pancreatic lipase inhibitor. Antiobesity agent.

2. Antidiabetic

3. Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.

4. Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption. Tetrahydrolipstatin is widely used for the
treatment of obesity.


Advantage

1. We have experience in exporting Pharma Chemicals, as you know, EU places much emphasis on them, and you must find a experienced partner who will assure you;

2. Quality: Our company is a professional leading factory in China in pharmaceutical area, We had stable customers and exported to Germany, Spain, UK, USA, Australia, Middle East, and any other countries. We can provide good references about our company. As for the quality of the products, we 're sure they can satisfy you well enough;

3. Package: Professional packing with professional materials

4. Delivery: We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.

5. Service: Best Service with after-sales service and consultation!

 

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