Pharmacological effects Mudanpi 1. Effect on Cardiovascular: Mudanpi can increase coronary blood flow, reduce cardiac output, and reduce left ventricular work for anesthetized dogs. It has obvious protective effect on experimental myocardial ischemia, and it has a longer duration and reduces myocardial oxygen consumption. Danpi decoction, decoction after peoniflorin 1.0-3.0g/kg or marigold 80-120mg/kg intravenous injection, have an antihypertensive effect on anesthetized dogs and rats. Primary and renal hypertensive dogs were lavaged with 5 g/kg of peony skin decoction for 5 consecutive days. The dose increased to 10 g/kg on the 6th day and the 7th day, and blood pressure decreased significantly. Renal hypertensive dogs were given 10 g/kg decoction with peony phenol and the blood pressure dropped for 10 consecutive days. With peony phenol 0.5-1.0g/kg to renal hypertensive dogs and rats also showed a certain antihypertensive effect. Peony phenol can significantly inhibit the uptake and beating frequency of 45Ca in the fast phase (5 minutes) and slow phase (120 minutes) of normal cardiomyocytes, significantly inhibit the uptake of 45Ca in calcium abnormal cardiac myocytes and decrease the content of intracellular lipid peroxide in a dose-dependent manner. It shows that peony phenol can reduce the abnormal calcium injury and prevent Ca2+ influx and anti-oxidation. In addition to inhibiting calcium uptake, sodium paeonolsulfonate significantly inhibited 45Ca uptake and membrane SA content in calcium abnormal cardiac myocytes, which was correlated with dose. In addition, atherosclerosis model of prey was used to study the anti-atherosclerosis effects of phytol. Morphological grading and morphological histochemical analysis of aortic endometrial lesions in the phenomenological and bolon groups were all significantly less than those in the styling control group. It was indicated that intraperitoneal injection of bronchiolone 100 mg/kg·d for 6 weeks significantly inhibited the formation of atherosclerotic plaque. 2. Effects on the central nervous system: Paeonol has antipyretic effect on mice with fever caused by oral typhoid fever and paratyphoid fever and lowers body temperature in normal mice. Oral paeonol can inhibit the writhing response and tail tenderness in mice induced by intraperitoneal injection of acetic acid, and can overcome the caffeine-induced hyperactivity of the mice, and can significantly prolong the sleep time of mice induced by cyclamate. At high doses, the mice's righting reflexes disappear, and they can significantly counteract convulsions caused by pentylenetetrazol, strychnine, nicotine, and electroshock. The site of action is in the midbrain reticular formation and the thalamus. 3. Anti-inflammation: Paehritis with paeonol has inhibitory effects on edema induced by dextran or acetic acid or carrageenan, and can inhibit acetic acid or serotonin-induced mouse abdominal or guinea pig skin Capillary permeability increases, inhibiting stress ulcers in mice. Experiments show that Dan Pi Shui decoction has an inhibitory effect on various inflammatory reactions caused by carrageenan edema, adjuvant arthritis and arthus reaction, which is related to its inhibition of inflammatory tissue permeability and inhibition of PGE2 biosynthesis , Dan Pi can not inhibit the compensatory hyperplasia of the remaining adrenal glands, also has no significant effect on the adrenal vitamin C metabolism, suggesting that it has no cortisone-like effect, and no corticosteroid-like effect, that is, its anti-inflammatory The effect does not depend on the pituitary adrenal system. Type I, II, and III allergic reactions are responses mediated by specific antibodies, and paeonol has no significant effect on the formation of antibodies, but all have inhibitory effects on them, probably through non-specific anti-inflammatory mechanisms, and inhibit Serum complement activity also enhances its anti-inflammatory effects. Paeonol does not inhibit the production of specific antibodies and does not affect the hemolytic activity of the complement alternative pathway, suggesting that moutan bark can not inhibit normal humoral immune function while exerting anti-inflammatory effects. 4. Antimicrobial effect: In vitro experiments showed that Mudanpi decoction against Bacillus subtilis, Escherichia coli, Salmonella typhi, Paratyphoid bacillus, Proteus, Pseudomonas, Staphylococcus, hemolytic streptococcus, pneumococcus, Vibrio cholerae, etc. All have a strong antibacterial effect. Peony leaf decoction has a significant antibacterial effect against Shigella, Pseudomonas aeruginosa, and Staphylococcus aureus. Its effective ingredient is gallic acid. Chicken embryo experiments showed that Mudanpi decoction has inhibitory effects on influenza virus, but the results of mouse treatment experiments are inconsistent, so its antiviral effect is not yet certain. The relationship between the antibacterial components of the water decoction and the thermal stability of the peony bark was discussed. It was suggested that the in vitro antibacterial activity of mulberry bark after boiling for 30 minutes was better than that of decoction with a decocting time of 15 minutes, but there was no significant difference in the antibacterial capacity of water decoction with decocting time of 60 and 90 minutes. 5. Anticoagulant effect: In vitro human platelet test, found that water extract of Paeonia peel cortex and Paeoniol can inhibit platelet arachidonic acid production of thromboxane A2, thereby inhibiting platelet aggregation, which is due to inhibition of arachidonic acid to prostate H2 The result of the cyclooxygenase reaction. The methanol extract of Cortex Moutan can inhibit the experimental thrombus induced by endotoxin. Studies have shown that the mechanism of anti-thrombosis of tree peony bark is: paeonol, benzoyl oxime and benzoyl oxime drugs inhibit platelet aggregation, while paeonol, paeoniflorin, lanthanum oxime have anti-opsonizing effect; benzene Formyl oxime drugs have the effect of blocking plasminogen activation and anti-fibrinolysozyme; stilbene oxide, benzoyl peroxide guanidine, and benzoylguanidine have a strong stabilizing effect on red membranes. This inhibits thrombosis. Rats were intraperitoneally injected with paeoniflorin or inhibited ADP- or collagen-induced platelet aggregation in vitro. 6. Effects on the immune system: Mushrooms were administrated with peony bark, paeonol, paeoniflorin, stilbene, and benzoyl hydrazone respectively, all of which promoted the clearance of carbon particles in the blood, even though Mononuclear macrophage system function is also promoted in a low state, microscopy shows Kupffer cells in the liver and spleen macrophage phagocytosis increased. Paeoniflorin and lanthanum oxide can enhance the phagocytic function of mouse peritoneal macrophages on the emulsion in vitro. The intraperitoneal injection of Danpi liquid to mice can increase the number of spots after the spleen hemolysis. Intraperitoneal injection of paeonol into mice at a dose of 25 mg/kg each for 6 days resulted in a significant increase in spleen weight, and could counteract the weight loss of thymus caused by cortisone and cyclophosphamide. It can be seen from the above that moutan bark enhances humoral and cellular immunity. 7. Effects on lipid metabolism: Danpi and its contained paeonol, paeoniflorin have an inhibitory effect on the adipocyte-induced lipolysis of fat cells; Danpi water extract can increase glucose production of fat cells in fat cells, It also significantly increases insulin-induced glucose production. 8. Other effects: Instilling into the abdominal cavity with 20% Danpithin has a significant preventive effect on rabbits with traumatic intraperitoneal adhesions. In rats injected with Freund's adjuvant, chronic inflammation of the arthritis, subcutaneous injection of the inflammatory agent casein in rats within two months can cause degeneration of the arthritic paws and tails to continue to deteriorate and subcutaneous fibrosis of the foot and tail. Bone hyperplasia, osteofibrosis, and connective tissue proliferation are also found in the subcutaneous tissue of the abdomen. If a continuous supply of moutan or Guizhi Fuling pills is given simultaneously with the enzyme protein, it can inhibit the new induced damage of the enzyme protein. The ethanol extract from Paeonol had inhibitory effects on Ehrlich ascites carcinoma cells and cervical cancer cells. Paeonol has a certain inhibitory effect on the metabolism of benzopyrene in rat liver microsomes. It has anti-pregnancy effect on mice and has a diuretic effect on rats. electric Linear Actuator is AOMEKE specially designed for smart furniture such as sofa, maximum load is 150kg,a linear slide to move a load, instead of an extension tube. This linear slide mechanism allows for a significantly shorter retracted length and makes the AK-MP141 a great solution for various smart furniture applications. The AK-MP141 is designed to function as a direct cut system, eliminating the need for a control box, offering a simple and economical solution. 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