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The French National Research Center issued a communique on the 22nd, saying that researchers at the agency have discovered that the adipose tissue of mice can produce immune cells against allergies and inflammation. This research has subverted the previous views of the scientific community and contributed to the development of new drugs. .
According to the communique, adipose tissue is not only a "repository" of oils, but also plays an important role in the biological metabolism. For example, white adipose tissue contains macrophages and lymphocytes in the blood. These hematopoietic cells are in white adipose tissue. About 20% of the total. Previously, it has been thought that these hematopoietic cells can only be derived from bone marrow and are isolated from hematopoietic stem cells.
However, the researchers at the National Research Center have come to different conclusions. They found through experiments that the adipose tissue of the mouse itself can produce hematopoietic stem cells, which in addition to differentiated hematopoietic cells, will also differentiate into mast cells. Mast cells are immune cells that play a vital role in the body's fight against allergies and inflammation.
The researchers say that mast cells are ubiquitous in the immune system, and their effects are much larger than people think, and adipose tissue usually accounts for 10% to 50% of an adult's body weight, if they can further prove the body's adipose tissue. It can also produce mast cells, which will bring hope to patients with hematopoietic and immune system diseases. The research results have been published in the latest issue of the US Journal of Stem Cells.