Analysis of the Quality of 95% Thiazole (Yetzol) Prodrug

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Zhejiang Longwan Chemical Co., Ltd. 95% Thiazole (Yetzol) Original Drug

Dragon Brand Boutique “Titrazol” (Yetzol) (20% WP)

1、Technical content of Dragon brand thiazole

Dragon brand thiazole is a self-invasive therapeutic bactericidal preparation. Dragon brand thiazole is a new thiazole agent that controls bacterial diseases in crops. It has high efficacy and low toxicity. In 1979, he won the second prize of Zhejiang Science Conference. From 1982 to 1984, it was successfully developed by the Wenzhou Engineering Institute of Zhejiang Province and Wenzhou City Agricultural Institute. Formally put into production in 1982, in the use of field to achieve better control effect. It was put into production in 1984 and won the second prize of scientific and technological achievements in Zhejiang Province.

Zhejiang Longwan Chemical Industry Co., Ltd. annually produces 1050 tons of 95% thiazole (yelzuzole) original drug and 1050 tons of 20% thiazole (Yetzol). It is currently the largest thionidazole drug in the country and Yezizole. Formulate R&D, manufacturing and manufacturing enterprises, with perfect production equipment and advanced R&D technology. Each year, Thiophene (Yetzol) is exported to hundreds of tons of Southeast Asian countries. "Longpan" is a registered trademark of Zhejiang Longwan Chemical Co., Ltd. “Ye Qing Shuang” is a registered trade name of this product of Zhejiang Longwan Chemical Co., Ltd. (TM, Trade-Mark)

"Technical production of thionidazole" was included in China's Export-Restricted Export Technology Catalog No. 982903X, and it belongs to China's independent intellectual property chemical pesticide production technology.

2. The bactericidal mechanism of thiobite, the ultra-fine product of Dragon Brand:

Long brand superfine thiophene thiazole is a new type of heterocyclic bactericide, has a strong internal permeability, at the same time has a therapeutic and preventive role, the treatment effect is more significant.

The thiazole group is a highly effective therapeutic agent in plants, and the agent is severely damaged in the plant's holey catheter. The cell wall becomes thin and then collapses, resulting in the death of the bacteria.

The mechanism of action of thiophenazole, a superfine product of Long Brand, is an esterase system that interferes with the amino acid metabolism of pathogens through thiadiazole, destroys the biosynthesis of proteins, inhibits the growth of mycelium and causes cell pellets, and causes the loss of reproduction and infestation of pathogenic bacteria. Ability to achieve the purpose of killing pathogens and preventing diseases.

Long brand superfine quality thiazolyl is mainly used for the prevention and control of plant bacterial diseases, and it is ideal for field control of crop bacterial diseases.

3. Introduction of Dragon Brand Thiophenazole (20% WP):

Ministry of Agriculture Official Registration Number of pesticides: PD86153-8

Pesticide production approval certificate: HNP33036-D0173

Product quality standard number: Zhejiang B/HG182-87

English common name: bismerthiazol

Chemical name: N.N'-methylene-bis(2-amino-5-thio-1,3,4-thiadiazole)

CAS: 79319-85-0

Molecular Formula: C5H6N6S4

Molecular weight: 278.38

Chinese name: N,N-methylene-bis(2-amino-5-mercapto-1,3,4-thiadiazole);

English name:

N,N-Methylene bis(2-amino-5-mercapto-1,3,4-thiadiazole)

Chinese common name: thiazolyl, methimazole;

Product Name: Ye Qingshuang, Chuanhua-018, Ye Kuning.

4. Longitudinal quality thiazole in nature Description:

Dragon brand quality thiazole, white rectangular column crystal or light yellow loose powder, melting point 190 °C 1 °C, decomposition temperature 200 °C. Soluble in dimethylformamide, dimethyl sulfoxide, pyridine, ethanol, methanol, etc., insoluble in water. More stable to alkali.

Dragon brand quality thiothiazide toxicity LD50 (mg/kg): rat acute oral (the original drug) LD503160 ~ 8250mg/kg; mouse 3480 ~ 6250 mg/kg. The rats were fed with 0.25 mg/kg for one year without bad shadows. Teratogenic carcinogenic mutagenicity tests are all within the safe range. Use of human and animal safety. No allergic and dermatitis symptoms were observed during the production process.

5, Dragon brand quality thiopicazole Note:

Dragon brand quality thiazole azole is a low-toxic bactericide, chemically stable. In use or after use, if the body is unwell, it should immediately go to the hospital for treatment and symptomatic treatment according to the symptoms.

6, Dragon brand quality thiazole technology preparation:

It is prepared from hydrazine hydrate, sodium thiocyanate, formaldehyde and carbon disulfide as raw materials. Hydrazine hydrate reacts with sulfuric acid to form barium sulfate, which is then reacted with sodium thiocyanate under the action of a catalyst to form dithiourea and sodium sulfate. Under the action of the catalyst, carbon disulfide is used for the ring closure reaction to produce 2-amino-5. Thio-1,3,4-thiadiazole; must finally be condensed with formaldehyde to produce mettilazole (thiazole) (this is the most important part to determine true and false Yeqing double).

7, Dragon brand thiazolyl use:

A systemic low toxicity germicide. It is mainly used to control bacterial diseases in crops. Preparations are 20% wettable powders. It is an excellent agent for the control of rice bacterial blight, rice bacterial streak disease, citrus canker disease, cabbage soft rot. It has good internal absorption and conduction, and it has preventive and therapeutic effects. It has a long effective period, stable efficacy, and no harm to crops. The dragon brand thiazolyl tetrazolium mainly controls bacterial blight such as bacterial leaf blight, rice bacterial streak disease, cabbage soft rot disease, tomato bacterial wilt disease and citrus canker disease.

8, Dragon brand quality thiazolazole processing formulations are: WP and suspension agents.

9, Dragon brand boutique thiophene packaging and storage:

Zhejiang Longwan Chemical Co., Ltd. 20% WP is packed in plastic bags lined with kraft paper bags, 25, 100, 150, 200, 250 grams per bag, plus cartons, each box (20, 25, 50 bags or 100, 200 bags) ), Each item has a net weight of 5 or 7.5 kg. The large package is 50 kg brown paper bag.

10, Dragon brand quality thiazolyl use technology complete program:

1. Control bacterial blight of rice and bacterial bacterial streak of rice: In the early stage of rice onset and at the beginning of heading, or in the paddy field at the 4 to 5 leaf stage, use 20% WP wettable powder of 125 grams per mu. For water 75 ~ 100kg, foliar spray, spraying 2 times (interval 7 ~ 10 days) is appropriate.

2. Control of orange canker disease: The Mu brand dragon fine-quality thiazolyl 20% WP 100 to 150 grams, and the water 600 was sprayed with liquid. Spring shoots, summer shoots and shoots were sprayed 2–3 cm after the autumn shoots were sprayed, respectively, each spray 2 times. When the condition is serious, the dose may be increased appropriately without injury. General use of leaf spray, the use of Oriental Red mist mister control effect is better, the finer the spray atomization, the better. Not suitable for mixed soil application.

3, control of soft rot of cabbage: Each brand of phthalein used Ximu 20% wettable powder thiophene 100 ~ 150 grams, 600-800 times the water solution, can be sprayed or irrigated, continuous spraying 1-3 times, each The interval of 7 days or so, the control effect can reach more than 85%.

4, control of tomato bacterial wilt: Mu Yong brand quality thiazolyl 20% WP 100 to 150 grams, 600 times the water, the combination of irrigation and spray, continuous 2-3 times, each time interval 7 Days or so, the field control effect can reach more than 80%. (Xiong Xingping)

Manufacturer: Zhejiang Longwan Chemical Co., Ltd.

Address: No. 6 Huangshan Road, Airport Avenue, Wenzhou City, Zhejiang Province (Zip Code 325013)

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