Release date: 2008-02-20 Establishment of erythroid progenitor cell line by daily mouse embryonic stem cells
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The Japan Institute of Physical and Chemical Research has announced the establishment of a erythroid progenitor cell line using experimental mouse embryonic stem cells, and confirmed that red blood cells differentiated from this progenitor cell line can effectively treat acute anemia in experimental mice.
According to the Institute of Physical and Chemical Research, it is difficult to eliminate the infection of hepatitis and other diseases by transfusion of red blood cells. In the future, people may urgently need a technology that can synthesize red blood cells in large quantities.
Red blood cells are important blood components for transporting oxygen. Red blood cells cannot proliferate by themselves. In the human body, red blood cells are proliferated and differentiated by their progenitor cells. Therefore, in order to mass-produce red blood cells, it is necessary to proliferate a large number of red blood cell progenitor cells. Once the erythroid progenitor cell line is established, the progenitor cells can be proliferated to the required amount at any time in the test tube.
Researchers at the Institute of Physical and Chemical Research used eight experimental mouse embryonic stem cell lines and added trophoblasts and proliferation factors. A total of 63 differentiation induction experiments were performed, and five blood progenitor cell lines were obtained, three of which were erythroid progenitor cell lines. The researchers also asked the rats to develop severe acute anemia and then transplanted them into the erythroid progenitor cell line. As a result, 7 of the 8 experimental mice that received the transplantation survived, and 7 of the 8 diseased rats that did not transplant the erythroid progenitor cell line died.
Researchers are currently testing new technologies and hope to use this technology to develop safe human erythroid progenitor cell lines. ——China Medicine 123 Network 
