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Nootropic Supplement Drug Flumazenil 78755-81-4 White Powder for Strength Increasing
Description:
Flumazenil, an imidazobenzodiazepine, is a benzodiazepine antagonist which specifically blocks the
central effects of agents acting through the benzodiazepine receptor by competitive inhibition. In animal
experiments the effects of compounds showing no affinity for the benzodiazepine receptor, e.g.
barbiturates, ethanol, , GABA mimetics, adenosine receptor agonists and other agents were
not affected by flumazenil, but those of nonbenzodiazepine agonists of benzodiazepine receptors, such
as cyclopyrrolones (e.g. zopiclone) and triazolopyridazines were blocked.Â
Quick Details:
Chemical name: Flumazenil
MF:C15H14FN3O3
MW:303.29
CAS:78755-81-4
MOQ: 1g
Packing:10g/foil bag
Delivery time: 3~7 working days
COA:
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Product name
 Flumazenil
CAS No.
 78755-81-4
Outer Packing
 100G
Production date
 02-07-2016
Shelf life
 02-06-2018
Standard adopted
 USP33
Items of analysis
 Specification
 Results
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Appearance
White crystalline powder
White crystalline powder
Identification
The sample'S IR spectrum is according with spectrumÂ
Conforms
Melting pointÂ
198ºC to 202ºC
200.6ºC to 200.9ºC
Impurity C
 NMT 0.2%
0.02%
Impurity A
NMT 0.10%
Not detected
Impurity B
NMT 0.2%
0.03%
Impurity D
NMT 0.10%
0.03%
Impurity E
NMT 0.10%
Not detected
Impurity F
NMT 0.10%
Not detected
Individual unknown impurituy
NMT 0.10%
0.02%
Total impurities
NMT 0.5%
0.1%
Loss on dryingÂ
NMT 0.5%
0.2%
Sulphated ash
NMT 0.1%
0.05%
Heavy metals
NMT 20ppm
5ppm
Microbial limits( for Injection)
Bacteria not more than 50CFU/g
<10 CFU/g
Microbial limits
Mildew and microzyme not more than 50CFU/g
<10 CFU/g
Microbial limits
Escherichia coli absence
Absence
Ethanol
NMT2000ppm
Not detected
Chloroform
NMT30ppm
Not detected
Acetic AcidÂ
NMT4000ppm
Not detected
Dichloromethane
NMT600ppm
<0.002%
Ethyl ethanoate
NMT5000ppm
<0.003%
DMF
NMT750ppm
Not detected
Assay (On dried substance)
98.0-102.0%
99.80%
Struscture Characteristics:
Flumazenil is a white to off-white crystalline compound with an octanol: buffer partition coefficient of 14 to 1 at pH 7.4. It is insoluble in water but slightly soluble in acidic aqueous solutions. Flumazenil injection is available as a sterile parenteral dosage form for intravenous administration. Each mL contains 0.1 mg of flumazenil compounded with 1.8 mg of methylparaben, 0.2 mg of propylparaben, 0.9% sodium chloride, 0.01% edetate disodium, and 0.01% acetic acid; the pH is adjusted to approximately 4 with hydrochloric acid and/or, if necessary,
Medical uses:
There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil's short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms.
Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zolpidem, zaleplon and zopiclone.
It may also be effective in reducing excessive daytime sleepiness while improving vigilance in primary hypersomnias, such as idiopathic hypersomnia.
It has also been used in hepatic encephalopathy, though results have been mixed.
The onset of action is rapid and usually effects are seen within one to two minutes. The peak effect is seen at six to ten minutes. The recommended dose for adults is 200 μg every 1-2 minutes until the effect is seen, to a maximum of 3 mg per hour. It is available as a clear, colourless solution for intravenous injection, containing 500 μg in 5 mL.
Do NOT use flumazenil if:
you have been given a benzodiazepine for control of a potentially life-threatening condition (eg, increased pressure in the head, seizures)
you are experiencing side effects due to an overdose of a medicine used to treat depression
Contact your doctor or health care provider right away if any of these apply to you.
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