In two kinds of Incompatible Liquids, adding one kind of assistant can make one of the liquids dispersed in another liquid with very small particles or liquid beads, and become a more stable emulsion. This action is called emulsification, and the auxiliaries that play the role are called emulsifiers.
Surfactant is a substance which can significantly reduce the surface tension of solvent (generally water) or the interfacial tension between liquid and liquid, change the surface state of voxels and produce ethylene to meet the application requirements.
Emulsification, dispersion and solubilization. Solubilization: The presence of micelles increases the solubility of substances in solvents. This phenomenon is called solubilization.
Solubilization is different from emulsification. When one liquid is dispersed in the other, the system is unstable and eventually stratified. Solubilization can make the system more stable. When the surfactant concentration of the solution reaches the critical micelle concentration, the micelle can dissolve the oily substance in its own lipophilic part. In pesticide emulsifiers, surfactants have obvious solubilization effect on pesticides, which helps to improve the emulsifying performance, especially the stability, and can reduce the amount of emulsifiers.
Our Services
1. OEM(????) service is available.
2. Fast producing time.
3.Cheapest price forproduces.
4. Reply promptly in 24 hours.
5.Free sample available.
FAQ
Q1: product specifications?
A: we will pack the product specifications according to your needs.
Q2: Do you have some videos where we can see the line production?
A: Yes, we can provide some videos for reference. (yes, we can provide some videos).
Q3: How about payment terms? What kind of payment terms do you have?
A: 30% TT deposit + 70% TT before shipment, 50% TT deposit + 50% LC bala
Nce, Flexible payment can be negotiated.
Q4: what advantages do you have?
A: the quality of the products we offer can be guaranteed and will provide you with very competitive prices.
If you have any questions, please contact with us directly. Organic Intermediate are produced by HRT bearing With High Quality and Good Appearance. Welcome you can visit our Factory. For inqury, please send mail directly to us.
Pesticide Emulsifier,Emulsifier For Agriculture Pesticide,Pesticide Automatic Emulsifier,Pesticide Emulsifier For Agriculture Shandong Chenyi Environmental Protection Technology Co.,Ltd , https://www.chenyichemistry.com
Microscopic and dissolution characteristics of Tianma ultrafine powder
Microscopic and dissolution characteristics of Tianma ultrafine powder
This information is extracted from: Shandong Sanqing Stainless Steel Equipment Co., Ltd. Â Â Â Please call if necessary:
the company: or
Chen Changzhou, Sun Dongmei, Zhang Xiaojuan, Tu Yaosheng, Cui Jingchao (Guangdong Institute of Traditional Chinese Medicine, Guangzhou 510095, China)
Abstract: Objective ultrafine powder technology Gastrodiae ultrafine grinding, in order to improve the dissolution gastrodin.
Methods Ultrasonic extraction was carried out by micro-powder, and the content and dissolution of gastrodin were determined by high performance liquid chromatography.
Through a 400 mesh screen results Gastrodia micropowder T 50 is 9.2min, 100 ~ 120 mesh micropowder T 50 is 44.4min.
Conclusion: After ultrafine pulverization of Tianma, the dissolution of gastrodin of 400 mesh fine powder is obviously higher than that of 100~120 mesh, and the dissolution rate after powder granulation is still better than 100~120 mesh.
Key words: Gastrodia elata/chemistry; Gastrodin/Analysis; Chinese medicine ultrafine powder technology/instrument and equipment
CLC number: R284.1 Â Â Document identification code: A Â Â Â Article ID:1003-9783 (2002 )04-0251-02
Ultra-fine powder technology is a multi-disciplinary modern comprehensive science and technology, which has been successfully applied in materials, chemicals, metallurgy, electronics, medicine and food industries. The ultra-fine powder technology refines the material and increases the specific surface area. For the drug, the dissolution and release of the solid drug are improved, thereby improving the bioavailability of the drug. Traditional Chinese medicine has been used as a powder since ancient times. It has similarities with ultra-fine powder technology, and it is necessary to smash the original medicine. In other words, the ultra-fine powder technology is to refine the traditional powder, which suggests that we can use the powder as the ultra-fine powder technology in the application of Chinese medicine, to better improve the bioavailability of the powder. According to this idea, we have carried out research on a series of traditional Chinese medicine varieties. The research report of Tianma ultrafine powder is as follows.
1 Materials and methods
1, 1 medicinal materials and reagents   Gastrodia medicine is provided by a pharmaceutical factory in Guangdong. The gastrodia elata powder is made into 100-120 mesh, 250-300 mesh, and 400 mesh powder, respectively. A pharmaceutical factory Tianma formula particles, batch number 010434. A company full Tianma capsule, batch number 2001101, go to the capsule shell, mix and use. The gastrodin standard is provided by the China National Institute for the Control of Pharmaceutical Sciences. Methanol, analytically pure.
1, 2 instruments Standard sieve set, Sanqing micro-powder, OLYMPMSBH microscope. High Performance Liquid Chromatograph Agilent 1100 Series.
1,3 Method (1) After being coarsely pulverized, the gastrodia elata is put into the micro-powder machine, crushed at -10~-15 °C for 15 min, and 100~120 mesh, 250~300 mesh are prepared with special sieves of different specifications. Three fine-grain samples of 400 mesh were observed microscopically to observe the microscopic characteristics of each fineness sample. (2) Then, three kinds of fineness powders were respectively made into three kinds of particles of 100-120 mesh, 250-300 mesh and 400 mesh, and the gastrodin content was 0.1%. Weigh accurately 2.5g of each of the three kinds of samples, placed in a 250ml conical flask and accurately add 25ml of methanol, placed in an ultrasonic washer, adjust the water temperature of 40~45°C, and use a 0.45μm microfiltration syringe for 5min respectively. Samples were taken at 15 min, 30 min, 45 min, 60 min, and the gastrodin content was determined according to the literature [1] . Calculate the cumulative dissolution rate of gastrodin, refer to the literature [1] Weibull function calculation method to find its linear equation, the slope is m, and calculate the gastrodin gas dissolution 50% (T 50 ) and dissolution of 63.2% (T d ) time. The dissolution parameters were based on the "NDST New Drug Statistics Program" software, and the q test was used to compare the two.
2 results
2.1 Ultrafine powder microscopic characteristics   See Table 1.
2.3 The comparison results of the dissolution of Tianma particles are shown in Table 3.
Table 1 Â Â Â Â Â Â Â Â Â Â Â Microscopic characteristics of three kinds of fineness powder of Gastrodia elata
Fineness             Powder uniform state           Cells and catheters                 Needle crystal state
100~120 mesh         Uneven size,            More complete                 Suffocation
40×40?m, 160 ×160?m                    Â
250~300 mesh        More uniform size,           Cell wall and catheter            Not in bundle
40 × 40?m, 80 × 80?m        Fragments scattered                  Â
Passing 400 mesh      The size is quite uniform,        Almost seeing intact cells and catheters,    Needle crystal broken
10~40?m                Polysaccharide particles
2.2 Dissolution of ultrafine powder gastrodin   The results are shown in Table 2.
Table 2 Dissolution parameters of three kinds of fine gastrodia elata powder gastrodin (N=3)
Sample fineness m T 50 /min T d /min
100~120 mesh 0.645 44.4 78.5
250~300 mesh 0.640 22.6 39.9
Pass 400 mesh 0.972 9.2 13.4
2.3 The comparison results of the dissolution of Tianma particles are shown in Table 3.
table 3    Comparison of gastrodin release parameters of different samples (χ± s )
Sample fineness N/ batch m T d /min T 50 /min
100~120 mesh fine powder particles 5 0.549 ±0.22 63.84 ±22.95** 30.98 ±8.26**
400 mesh fine powder particles 5 0.702 ±0.11 10.66 ±1.60 6.33 ±1.42
Tianma Formula Granules 4 0.863 ±0.10 35.55 ±4.06* 23.15 ±2.40**
Whole Tianma Capsule 5 0.578 ±0.56 18.92 ±4.09 10.00 ±2.14
Note: *p<0.05, **p<0.01 compared to 400 mesh fine powder particles.
3 discussion
3, 1 research using ultra-fine pulverization technology to smash Tianma, with the increase of fineness, cell, catheter, needle crystal fragmentation degree increased, the fineness of 250~300 mesh, most cells have broken, to pass 400 mesh Almost all of the rupture, the polysaccharide particles are exposed, which is conducive to the dissolution and diffusion of the active ingredients. The dissolution test showed that the time required for gastrodin to dissolve 50% was shortened as the fineness was increased.
3, 2 Ultra-fine powder technology application of one of the big problems of Zui is that the powder is easy to adsorb and agglomerate each other, which brings a series of difficulties for the packaging, transportation and storage of drugs. In this study, the granulation method was used. The time required for the dissolution of 400 mesh granule gastrodin 50% was less than 100-200 mesh particles (p<0.05=, indicating that the granulation method was reasonable and feasible. The results of this study are available for Tianma formula granules. Manufacturer's reference.
Reference party:
[1] National Pharmacopoeia Commission, Pharmacopoeia of the People's Republic of China (2000 edition) [S], Beijing: Chemical Industry Press, 2000.453.
[2] Yu Xiangan, Cai Huaiyou, using the calculator to calculate the tablet dissolution parameter calculation procedure [J], Chinese pharmacy, 1995, 6 (4): 21.
Â