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The mechanism of the treatment of diabetic nephropathy
Research Institute of Traditional Chinese Medicine at Shanghai University of Traditional Chinese Medicine has confirmed that burdock fruit has therapeutic effects on the diabetic nephropathy (DN) mechanism and the reduction of urinary protein, urine microalbumin, and affecting renal tissue transforming growth factor p1 (TGF-p1) and monocyte chemoattractant protein 1 (MCP- 1) The expression of mRNA is related. The researchers used streptozotocin (STZ)-induced diabetic rats as animal models, and traditional Chinese medicine treatment groups were given bovine wolfberry powder feed, bovine wolfberry fruit water extract, and alcohol extracts for 6 weeks. The status and changes of urine protein, urinary microalbumin, and renal function were measured by polymerase chain reaction (RT-PCR) method to determine the expression of TGFp1 and MCP-1 mRNA in the renal cortex. The results showed that the extract of Chinese wolfberry fruit can significantly improve the STZ rat's polydipsia, more food and weight loss, reduce urine protein, urinary microalbumin, and reduce the expression of TGF-p1 mRNA and MCP-1 mRNA. According to the researchers, MCP-1 is the most important cytokine in the infiltration of tissue by monocytes, and it is the chemokine that mainly chemotizes and activates macrophages. The study suggests that the infiltration of monocytes in monocytes is associated with the accumulation of extracellular matrix and the development of glomerulosclerosis. Rovin et al. showed that DN-1 can synthesize MCP-1 in the kidney, and MCP-1 and kidneys are small. Ball injury related. The results of this experiment show that the treatment of bovine wolfberry fruit extract group can reduce the MCP-1 mRNA expression, compared with the normal group was no significant difference, and the model group, the water extract of Arctiin had significant differences. It is suggested that the extract of Fructus Arctii may improve the kidney damage of diabetic rats by reducing the expression of MCP-1 mRNA. Numerous experimental and clinical studies have shown that the expression of TGFp1 mRNA and protein content in the biopsy tissue of diabetic rats and diabetic nephropathy patients are significantly increased, accompanied by renal hypertrophy and extracellular matrix hyperplasia. The experimental results suggest that each drug group can reduce the expression of TGF-pl mRNA, and there is a significant difference compared with the model group; there is no significant difference between the Arctiate alcohol treatment group and the water extract group of Arctium burdock and normal group, and the burdock There were significant differences in the powder group. In addition, due to the presence of glomerular hyperperfusion in DN, the pressure across the capillaries increases, which can increase the production of mesangial cells and stroma. Mesangial cells have the characteristics of smooth muscle cells. When the pressure increases, the number and size of the cells increase, and the mRNA content of type IV collagen of the glomerular basement membrane increases at the time of high perfusion, and the glomerular basement membrane of the glomerular is thickened. Can cause mesangial diffuse, nodular lesions, resulting in DN. This study shows that Arctium jasminoides and its extracts can effectively reduce urinary microalbumin, and 24-hour urinary protein and endogenous creatinine clearance in diabetic rats. Arctium jasminoides and its extracts can reduce the blood glucose level of DN rats and reduce the excretion rate of urinary protein, indicating that it may protect the renal function by reducing the high filtration and high perfusion in the kidneys of DN rats.