Japanese scientists clone descendants of sterile mice

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The research team led by Japan’s Institute of Physical and Chemical Research, Wakayamahiko, announced on the 21st that the team cloned offspring for sex chromosome abnormalities in sterile mice. This result has greatly helped the study of infertility and other diseases. According to Kyodo News on the 21st, the experimental sterile mice are bisexual mice, have testes and ovaries, but because the size of the Y chromosome is twice that of normal mice, there is no sperm and egg, and it is infertile. The researchers implanted normal mouse oocyte nuclei into the tails of sterile mice, and after the formation of cloned embryos, embryonic stem cells with differentiated ability were extracted from the embryos. The researchers implanted embryonic stem cells into the embryonic counterparts of normal mice. After the embryos were formed, the embryos were implanted into the female mice. Of the 52 embryos implanted in females, two developed into pups and were born successfully. The results of the examination showed that these two pups were infertile and inherited defects in the Y chromosome abnormalities. Many genetically mutated mice are unable to reproduce and cannot preserve genetic information. The researchers believe that this achievement has allowed the continuation of mutated genes that could not be preserved in the past, enabling scientists to do further research on the mutated genes and help treat diseases such as infertility.

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