Chlorogenic acid is a phenolic natural product isolated from the leaves and fruits of dicotyledonous plants, including the coffee bean, . Structurally, chlorogenic acid is the ester of caffeic acid with the 3-hydroxyl group of quinic acid. Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee, but is also found widespread in plants and can be isolated from the leaves and fruit. This compound, long known as an antioxidant, also slows the release of glucose into the bloodstream after a meal.
Biological importance:
This acid is an important factor in plant metabolism. It is also an antioxidant and an inhibitor of the tumor promoting activity of phorbol esters; At concentrations as high as 100 µ G/L, does not inhibit the 5-lipoxygenase activity of ionophore-stimulated human polymorphonuclear leukocytes. Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of Type 2 Diabetes Mellitus and cardiovascular disease.
Main functions:
1) The protection to cardiovascular
A large number of experiments have show that Chlorogenic acid, as a kind of free radical scavenger and antioxidant, has a good protection to cardiovascular. Chang Cuiqing proved that chlorogenic acid has a preparatory prevention to the damage of endothelial cells induced by ox-LDL. Chlopcikova discovered that chlorogenic can protect Myocardium cell from being damaged by oxidant of Doxombiein, DOx and has a prominent inhibition of peroxidization of mitochondria envelope lipid induced by iron reserves dependence DOX. It goes to show chlorogenic acid can protect vascular endothelium cell by removing radical intermediate and antioxidant lipids and has a further prevention to arteriosclerosishypertension and thrombosis.
2) Anti-mutagens and anti-cancer
The experiment of animals shows that chlorogenic acid can prevent and inhibit colon cancer and stomach cancer. Jiang discovered chlorogenic acid brought bigger DNA fragments produced by tumor cells and its agglutination. Aryl hydrocarbon hydroxylase is an important Metabolizing Enzyme of polynuclear aromatic and its activeness would improve the mutagens of anti- polynuclear aromatic of tissue cells. Research in vitro discovered that chlorogenic acid can improve the activeness of Aryl hydrocarbon hydroxylase. It also can inhibit the formation of 8-OHdG and the grow of Escherichia foetidaStaphylococcus aureusblack hay bacillus and legionella.
3) Reduce blood fat
Veins have given chlorogenic the power of reducing cholesterol and triglycerides in the blood of rats. When adding chlorogenic acid to the food of rats, it discovered that the cholesterol in rats lungs and livers has also reduced.
4) Anti-leukemia
Chiang found that chlorogenic acid had light activeness of anti-leukemia by the experiment in vitro. J. Bandyopadhyay has proved that chlorogenic acid can inhibit Ber-Abl and c-Abl and induce the dead of the original lymphocytosis in the body of leukemia patients.
5) Adjust the immune function
The research in vitro has showed chlorogenic acid can obviously strengthen T cells caused by influenza as well as induce humans lymphocytes and albumen cells to produce 7-IFN and α -IFN. It can improve the lgG1 and Ll4 level of rats. In a recent research, it is discovered that chlorogenic acid has the ability to activate nerve cardiac troponin to strengthen the function of macrophages.
6) Lower glucose
It is proved by the research of Andrade-Cetto and Wiedenfeld H that
Chlorogenic acid has potential function in lowering glucose in animals body. The function may have relationships with the inhibiting of glucose-6- and the absorption of glucose.
Shelf Life: 2 Years
Storage: Store in cool and dry place, keep away from light.
Packing: 25Kg/Fiber Drum, double plastic bag inside, with carton outside. 1Kg/Bag, aluminum foil bag vacuum packing.
Product Name
Chlorogenic acid
Molecular Formula
C16H18O9
Molecular Weight
354.3087
CAS Registry Number
327-97-9
EINECS
206-325-6
Density
1.65g/cm3
Melting point
205-209°C
Chlorogenic acid is a phenolic natural product isolated from the leaves and fruits of dicotyledonous plants, including the coffee bean, . Structurally, chlorogenic acid is the ester of caffeic acid with the 3-hydroxyl group of quinic acid. Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee, but is also found widespread in plants and can be isolated from the leaves and fruit. This compound, long known as an antioxidant, also slows the release of glucose into the bloodstream after a meal.
Biological importance:
This acid is an important factor in plant metabolism. It is also an antioxidant and an inhibitor of the tumor promoting activity of phorbol esters; At concentrations as high as 100 µ G/L, does not inhibit the 5-lipoxygenase activity of ionophore-stimulated human polymorphonuclear leukocytes. Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of Type 2 Diabetes Mellitus and cardiovascular disease.
Main functions:
1) The protection to cardiovascular
A large number of experiments have show that Chlorogenic acid, as a kind of free radical scavenger and antioxidant, has a good protection to cardiovascular. Chang Cuiqing proved that chlorogenic acid has a preparatory prevention to the damage of endothelial cells induced by ox-LDL. Chlopcikova discovered that chlorogenic can protect Myocardium cell from being damaged by oxidant of Doxombiein, DOx and has a prominent inhibition of peroxidization of mitochondria envelope lipid induced by iron reserves dependence DOX. It goes to show chlorogenic acid can protect vascular endothelium cell by removing radical intermediate and antioxidant lipids and has a further prevention to arteriosclerosishypertension and thrombosis.
2) Anti-mutagens and anti-cancer
The experiment of animals shows that chlorogenic acid can prevent and inhibit colon cancer and stomach cancer. Jiang discovered chlorogenic acid brought bigger DNA fragments produced by tumor cells and its agglutination. Aryl hydrocarbon hydroxylase is an important Metabolizing Enzyme of polynuclear aromatic and its activeness would improve the mutagens of anti- polynuclear aromatic of tissue cells. Research in vitro discovered that chlorogenic acid can improve the activeness of Aryl hydrocarbon hydroxylase. It also can inhibit the formation of 8-OHdG and the grow of Escherichia foetidaStaphylococcus aureusblack hay bacillus and legionella.
3) Reduce blood fat
Veins have given chlorogenic the power of reducing cholesterol and triglycerides in the blood of rats. When adding chlorogenic acid to the food of rats, it discovered that the cholesterol in rats lungs and livers has also reduced.
4) Anti-leukemia
Chiang found that chlorogenic acid had light activeness of anti-leukemia by the experiment in vitro. J. Bandyopadhyay has proved that chlorogenic acid can inhibit Ber-Abl and c-Abl and induce the dead of the original lymphocytosis in the body of leukemia patients.
5) Adjust the immune function
The research in vitro has showed chlorogenic acid can obviously strengthen T cells caused by influenza as well as induce humans lymphocytes and albumen cells to produce 7-IFN and α -IFN. It can improve the lgG1 and Ll4 level of rats. In a recent research, it is discovered that chlorogenic acid has the ability to activate nerve cardiac troponin to strengthen the function of macrophages.
6) Lower glucose
It is proved by the research of Andrade-Cetto and Wiedenfeld H that
Chlorogenic acid has potential function in lowering glucose in animals body. The function may have relationships with the inhibiting of glucose-6- and the absorption of glucose.
Shelf Life: 2 Years
Storage: Store in cool and dry place, keep away from light.
Packing: 25Kg/Fiber Drum, double plastic bag inside, with carton outside. 1Kg/Bag, aluminum foil bag vacuum packing.
Product Name
Chlorogenic acid
Molecular Formula
C16H18O9
Molecular Weight
354.3087
CAS Registry Number
327-97-9
EINECS
206-325-6
Density
1.65g/cm3
Melting point
205-209°C
High Purity Chlorogenic Acid (CAS: 327-97-9)
Model NO.: CAS: 327-97-9
Molecular Formula: C16h18o9
Extraction Type: Solvent Extraction
Molecular Weight: 354.31
Appearance: Light Yellow-Brown Fine Powder
Item Number: Zl-002
Type: Herbal Extract
Form: Powder
Part: Flower
Trademark: ZELANG
Transport Package: 25kg/Drum, Inner with Vacuum Packing
Specification: ISO 22000
Origin: Nanjing, China
HS Code: 2932999099
Model NO.: CAS: 327-97-9
Molecular Formula: C16h18o9
Extraction Type: Solvent Extraction
Molecular Weight: 354.31
Appearance: Light Yellow-Brown Fine Powder
Item Number: Zl-002
Type: Herbal Extract
Form: Powder
Part: Flower
Trademark: ZELANG
Transport Package: 25kg/Drum, Inner with Vacuum Packing
Specification: ISO 22000
Origin: Nanjing, China
HS Code: 2932999099
Natural Plant Extract Chlorogenic Acid